The association of alcohol intake with serum lipid profile and its modification by ADH1B and ALDH2 polymorphisms: J-MICC Study

Sasakabe, Tae

The association of alcohol intake with serum lipid profile and its modification by ADH1B and ALDH2 polymorphisms: J-MICC Study

Sunday, 17 August 2014

Exhibit hall (Dena'ina Center)

Tae Sasakabe , Nagoya University Graduate School of Medicine, Nagoya, Japan

Guang Yin , Seinan Jo Gakuin University, Kitakyusyu, Japan

Mariko Naito, PhD , Nagoya University Graduate School of Medicine, Nagoya, Japan

Emi Morita, PhD , Nagoya University Graduate School of Medicine, Nagoya, Japan

Sayo Kawai, PhD , Nagoya University Graduate School of Medicine, Nagoya, Japan

Rieko Okada, PhD , Nagoya University Graduate School of Medicine, Nagoya, Japan

Takashi Tamura, PhD , Nagoya University Graduate School of Medicine, Nagoya, Japan

Hiroko Nakagawa, PhD , Nagoya University Graduate School of Medicine, Nagoya, Japan

Shino Suma , Nagoya University Graduate School of Medicine, Nagoya, Japan

Nana Fukuda, MS , Nagoya University Graduate School of Medicine, Nagoya, Japan

Yuka Sugimoto, MS , Nagoya University Graduate School of Medicine, Nagoya, Japan

Kenji Wakai, PhD , Nagoya University Graduate School of Medicine, Nagoya, Japan

Nobuyuki Hamajima, PhD , Nagoya University Graduate School of Medicine, Nagoya, Japan

J-Micc Study Group , Nagoya University Graduate School of Medicine, Nagoya, Japan

INTRODUCTION: Although the association between alcohol intake and serum lipid profile has been reported, the alcohol metabolism depends on the polymorphism of related genes. The aim of this study was to assess the association and its modification by polymorphisms of alcohol metabolizing enzymes.

METHODS: This cross-sectional study included 1,020 men aged 35-69 years (mean age ± SD: 55.6 ± 8.9 years) who participated in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). The polymorphisms examined were ADH1B His47Arg (rs1229984) and ALDH2Glu487Lys (rs671). Alcohol intake and other lifestyle factors were assessed with a questionnaire. We regressed serum log-triglyceride (TG, mg/dl), LDL-cholesterol (LDL-C, mg/dl) or HDL-cholesterol (HDL-C, mg/dl) on alcohol intake (g/day) after adjusting for age, energy intake and physical activity. We categorized the subjects into two groups, namely, those with minor allele(s) and those without.

RESULTS: The distribution of the genotypes was as follows; 58.6% for His/His, 35.6% for His/Arg and 5.8% for Arg/Arg of ADH1B and 54.9% for Glu/Glu, 37.6% for Glu/Lys and 7.6% for Lys/Lys of ALDH2. All the examined serum lipids were significantly associated with alcohol consumption; coefficients for alcohol intake (β) as an explanatory variable were 0.0020 (95% CI: 0.0009-0.0031) for TG, –0.1494 (–0.2147 to –0.0841) for LDL-C, and 0.1111 (0.0776-0.1447) for HDL-C. A difference in β between the genotype groups was found only for TG; the β was 0.0031 (95% CI: 0.0017-0.0046) for His/His and 0.0005 (–0.0012-0.0021) for His/Arg and Arg/Arg for ADH1B and 0.0021 (95% CI: 0.0006-0.0035) for Glu/Glu and 0.0001 (–0.0021-0.0023) for Glu/Lys and Lys/Lys for ALDH2, and the increase in TG with an increasing alcohol intake (g/day) was greater in those without a minor allele.

CONCLUSIONS: Serum lipid profile was influenced by alcohol intake and ADH1B polymorphism may modify the association between triglyceride and alcohol consumption.