Dengue infection in HIV-1 positive patients: a challenge for health programs in Mexico

Sunday, 17 August 2014
Exhibit hall (Dena'ina Center)
Uriel A López-Lemus, PhD , Institute for Epidemiological Diagnosis and Reference, Mexico, DF, Mexico
Salvador Valle-Reyes, MS , University of Colima, Colima, Colima, Mexico
Clemente Vázquez-Jimenez, PhD , University of Colima, Colima, Mexico
Iván Delgado-Enciso, PhD , University of Colima, Colima, Mexico
Roberto Vázquez-Campuzano, BS , Institute for Epidemiological Diagnosis and Reference, Mexico, DF, Mexico
José A Díaz-Quiñonez, PhD , Institute for Epidemiological Diagnosis and Reference, Mexico, DF, Mexico
Carmen Guzmán-Bracho, PhD , Institute for Epidemiological Diagnosis and Reference, Mexico, DF, Mexico
Francisco Espinoza-Gómez, PhD , University of Colima, Colima, Mexico
INTRODUCTION:  

The HIV/dengue virus interaction in tropical areas has been little described. Previous studies have shown that dengue virus infection has a negative effect on the pathology of HIV/AIDS, and consequently less severe clinical complications. However, the molecular evolution of dengue virus could generate an unpredictable clinical course in HIV patients, specifically, where both viruses are predominant due to the high rates of infection. This report evaluates the effect of dengue serotype 1 infection in HIV patients in a tropical area from Mexico and it analyzes the epidemiological impact of these coinfections in tropical areas.

METHODS:  

Seven HIV-1 positive patients were analyzed in a tropical area from México. All of them were positive for Dengue virus serotype 1 (DENV1) infection through RT-PCR technique. A follow up of HIV-1 viral loads was performed during dengue infection and six months after co-infection. This protocol was approved by the Institutional Review Board of the School of Medicine, University of Colima.

RESULTS:  

Seven HIV-1 positive patients co-infected with DENV1 were analyzed in our laboratory. HIV-1 viral load was not significant during one year of follow up. Severe complications were not observed during dengue infection.

CONCLUSIONS:  

This report shows the course of HIV-1 viral loads during a dual infection with DENV1 in humans. There is little evidence about HIV/DENV co-infection in tropical regions. The search of evidence regarding HIV/DENV interaction in humans can provide new tools for understanding the epidemiological panorama of dengue transmission in HIV patients, and provide new tools for developing new strategies against HIV infection. The low rate of these co-infections is due to the lack of early clinical/molecular diagnosis, and difficulty of detecting these co-infections in both rural and urban areas. Epidemiological studies are required to understand the natural behavior of both pathogens when interact each other in the human population.

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