Temporal and regional variations in sporadic Creutzfeldt-Jakob disease in Japan, 2001–2010

Nakatani, Eiji

Temporal and regional variations in sporadic Creutzfeldt-Jakob disease in Japan, 2001–2010

Sunday, 17 August 2014

Exhibit hall (Dena'ina Center)

Eiji Nakatani, MS , Translational Research Informatics Center, Kobe, Japan

Tsutomu Nishimura, PhD , Translational Research Informatics Center, Kobe, Japan

Bin Zhou, PhD , Translational Research Informatics Center, Kobe, Japan

Hideaki Kaneda, PhD , Translational Research Informatics Center, Kobe, Japan

Satoshi Teramukai, PhD , Kanazawa University, Kanazawa, Japan

Yoji Nagai, PhD , Translational Research Informatics Center, Kobe, Japan

Masanori Fukushima, PhD , Translational Research Informatics Center, Kobe, Japan

Yasuhiro Kanatani, PhD , National Institute of Public Health, Saitama, Japan

INTRODUCTION: The objective of this study was to examine temporal and regional variations of sporadic Creutzfeldt-Jakob disease (sCJD), based on the Japanese national surveillance data from 2001 to 2010.

METHODS: We calculated the incidence of sCJD by age and sex, derived the standardized incidence in each of 47 prefectures, and performed spatial disease clustering analysis.

RESULTS: The average annual incidence of sCJD was 1.026 per million in men (637 patients) and 1.132 in women (733 patients), a significant gender difference after adjustment for age (P=0.001). The ratios of familiar CJD to sCJD apparently increased from 2001-2005 to 2006-2010, which is likely to be due to the nationwide introduction of genetic tests after 2006. Based on the data between 2006 and 2010, certain geographical clusters of sCJD were identified, where, incidence of sCJD was higher in certain specific prefectures compared the nation’s average.

CONCLUSIONS: sCJD appears to have regional variations, suggesting the existence of genetic or region-specific factors affecting the incidence of the disease.