Interaction between interleukin1-β gene polymorphism and cigarette smoking on HbA1c in a Japanese general population

Nishida, Yuichiro

Interaction between interleukin1-β gene polymorphism and cigarette smoking on HbA1c in a Japanese general population

Monday, 18 August 2014

Exhibit hall (Dena'ina Center)

Yuichiro Nishida, PhD , Saga University, Saga, Japan

Megumi Hara, PhD , Saga University, Saga, Japan

Hinako Nanri, PhD , Showa University, Tokyo, Japan

Kazuyo Nakamura, PhD , St. Mary's College, Fukuoka, Japan

Takeshi Imaizumi, PhD , Saga University, Saga, Japan

Tatsuhiko Sakamoto, PhD , Fukuoka Institute of Health and Environmental Sciences, Fukuoka, Japan

Yasuki Higaki, PhD , Fukuoka University, Fukuoka, Japan

Naoto Taguchi, PhD , Saga University, Saga, Japan

Mikako Horita, BS , Saga University, Saga, Japan

Koichi Shinchi, PhD , Saga University, Saga, Japan

Keitaro Tanaka, PhD , Saga University, Saga, Japan

INTRODUCTION: Both inflammation and cigarret smoking are known as majar risk factors for type 2 diabetes. We, therefore, investigated possible gene-environmental interactions between several inflammation-related gene polymorphisms and cigarette smoking on the level of HbA1c in a Japanese general population.

METHODS: We performed cross-sectional analysis using data collected from 2638 individuals (1281 men and 1357 women) aged 35–69 years who participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study (J-MICC study). Nine polymorphisms in 8 inflammatory genes (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-13, and TNF-α) were examined. Associations between the inflammatory polymorphisms, smoking, and HbA1c were assessed by multiple regression analysis and analysis of covariance, with adjustment for potential confounders.

RESULTS: A significant interaction was detected between IL-1β gene polymorphism and smoking status (P = 0.0005), with greater multiple regression coefficient in TT, compared to the CC and TC. In individuals with TT, the level of HbA1c was significantly higher in smokers than that in non-smokers (P= 0.0125), while HbA1c levels were similar in the subjects who have C allele.

CONCLUSIONS: The current results suggest that individuals with TT genotype of IL-1β gene polymorphism may have greater deleterious influence of cigarette smoking on HbA1c in middle-aged Japanese people.

This study was conducted for The J-MICC Study Group.