Association between Serum Uric Acid level and Metabolic Syndrome and its Sex Difference in a Chinese Community Elderly Population
This study aimed to evaluate the association between serum uric acid (SUA) and metabolic syndrome (MetS) among Chinese community elderly and explore the sex difference.
METHODS:
We conducted a population-based cross-sectional study in a representative urban area of Beijing between 2009 and 2010. A two-stage stratified clustering sampling method was used and 2102 community elderly were included in the study.
RESULTS:
The prevalence of hyperuricemia and MetS was 16.7% and 59.1% respectively. There was a strong association between SUA level and all five components of MetS in women and only three components in men. Multiple logistic regression analysis showed the odds ratio (OR) of hyperuricemia for MetS was 1.25(95%CI: 1.13-1.39) in men and 1.51 (95%CI: 1.35-1.67) in women. Even in the normal range, the ORs for MetS and its individual components increased gradually according to SUA levels. Compared with the lowest quartile of SUA, the adjusted ORs were 0.97(95%CI: 0.66-1.43), 1.52(95%CI: 1.03-2.23), 1.85(95%CI: 1.26-2.72) in men and 1.59 (95%CI: 1.15-2.20), 1.85 (95%CI: 1.34-2.56), 3.95 (95%CI: 2.76-5.66) in women for the second, third and top quartiles. A significantly liner-trend increasing in the number of MetS components across quartile of SUA was observed in both sexes (adjusted p for trend<0.001).
CONCLUSIONS:
This study suggests that higher SUA levels are positively associated with MetS and its components among Chinese community elderly, and it’s stronger associated in women than men, which is opposite to the adults’ results. . Physicians should recognize MetS as a frequent comorbidity of hyperuricemia and take early action to prevent subsequent chronic disease burden.