Ankle-brachial index and the risk of cardiovascular disease: The circulatory risk in communities study

Cui, Renzhe

Ankle-brachial index and the risk of cardiovascular disease: The circulatory risk in communities study

Monday, 18 August 2014

Exhibit hall (Dena'ina Center)

Renzhe Cui, PhD , Osaka University, Suita, Japan

Kazumasa Yamagishi, PhD , University of Taukuba, Taukuba, Japan

Hironori Imano, PhD , Osaka University, Suita, Japan

Tetsuya Ohira, PhD , Fukushima Medical University, Fukushima, Japan

Takeshi Tanigawa, PhD , Ehime University, Ehime, Japan

Masahiko Kiyama, PhD , Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan

Takeo Okada, PhD , Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan

Akihiko Kitamura, PhD , Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan

Hiroyasu Iso, PhD , Osaka University, Suita, Japan

INTRODUCTION:

Peripheral artery disease (PAD) is recognized as a risk factor for coronary heart disease and ischemic stroke in Western populations. However, evidence for the risk in Asian populations is limited.

METHODS:

This study examined 939 Japanese men aged 60-74 years. None of the subjects had a history of clinical PAD or cardiovascular disease. The ankle brachial blood pressure index (ABI) provided a surrogate measure of PAD.

RESULTS:

Age-adjusted risks of coronary heart disease, ischemic stroke, and ischemic cardiovascular disease were higher in men who measured in the lowest ABI tertile compared with those in the highest tertile. These associations did not change substantially after adjusting for cardiovascular risk factors. The respective multivariable hazard ratios (HRs; 95% CI) for the three conditions were: 2.48 (1.08-5.71), p for trend = 0.03; 1.95 (0.94-4.02), p for trend = 0.04; and 2.16 (1.25-3.72), p for trend = 0.004. These results did not vary with comparison of the three ABI categories: ≤0.90, 0.91-1.10, and >1.10. The multivariable HRs (95% CI) for an ABI ≤0.90 versus >1.10 were: 2.04 (0.67-6.20), p for trend = 0.14 for coronary heart disease; 3.39 (1.10-10.5), p for trend = 0.006 for ischemic stroke; and 2.61 (1.19-5.76), p for trend = 0.003 for ischemic cardiovascular disease. There was no association between ABI and the risk of hemorrhagic stroke.

CONCLUSIONS: Low ABI is associated with the risks of coronary heart disease, ischemic stroke, and ischemic cardiovascular disease in elderly Japanese men.