A case-control study to detect genetic and acquired risk factors for pediatric inflammatory bowel disease

Kobashi, Gén

A case-control study to detect genetic and acquired risk factors for pediatric inflammatory bowel disease

Tuesday, 19 August 2014

Exhibit hall (Dena'ina Center)

Gén Kobashi, MD , Chiba University Graduate School of Medicine, Chiba, Japan

Akira Hata, MD , Chiba University Graduate School of Medicine, Chiba, Japan

Keiichi Uchida, MD , Mie University Graduate School of Medicine, Tsu, Japan

Takashi Ishige, MD , Gunma University Graduate School of Medicine, Maebashi, Japan

Daiki Abukawa, MD , Miyagi Children's Hospital, Sendai, Japan

Hitoshi Tajiri, MD , Osaka General Medical Center, Osaka, Japan

Kan Uchiyama, MD , The Jikei University Kashiwa Hospital, Kashiwa, Japan

Yoshio Hirota, MD , Osaka City University Faculty of Medicine, Osaka, Japan

Masaki Nagai, MD , Saitama Medical University, Moroyamamachi, Japan

The Japan pediatric inflammatory bowel disease research Group , Chiba University Graduate School of Medicine, Chiba, Japan

INTRODUCTION: Pediatric inflammatory bowel disease (PIBD) is considered to be a multifactorial disease with both genetic and acquired factors involved in its etiology. Proposed acquired factors include lifestyles and environmental factors of both patients in childhood and their mothers in perinatal period. However, to date, few studies have been examined these factors simultaneously and clarified their confounding factors. This paper reports preliminary results of a case-control study which aims to elucidate genetic and acquired risk factors for PIBD and their confounding factors.

METHODS: PIBD cases and controls were recruited from affiliated hospitals of the Japan pediatric inflammatory bowel disease research group. Saliva sample of patients for genotyping and self-administrated questionnaire for their mothers were obtained with written informed-consent.

RESULTS: Sixty-five PIBD patients, including 43 ulcerative colitis (UC) and 22 Crohn’s disease (CD), and 62 controls were recruited to the study. An analysis of family history, gestational factors and past history revealed that family history of IBD and past history of surgical operation showed a positive association with CD, while no significant associations were found in parental smoking, birth weight and breast-feeding.

CONCLUSIONS: The present study is expected to develop early and individualized measures to prevent PIBD, intervention for lifestyles and environmental factors of expectant mothers possessing genetic risk factors for baby‘s future PIBD manifestation. Furthermore, the results may contribute to clarify new pathogenesis of PIBD manifestation and to produce more useful disease classification of PIBD.