Pattern and predictors of dyslipidemia in patients with type 2 diabetes mellitus
METHODS: The cross-sectional study is conducted among 366 consecutive eligible T2DM patients aged more than 30 years, BIRDEM diabetic hospital, during July-to-December 2010. Physical examination, diabetic profile, lipid profile and serum createnine was performed.
RESULTS:
Adjusted odds ratio and confidence limit were generated through binary logistic regression. Most frequent form (59.3%) of dyslipidemia is low HDL. Duration of T2DM is significantly correlated with TC (P < 0.05), HDL (P < 0.05) and LDL (P < 0.05) in both male and female. Glycemic control in terms of HbA1c >7% appeared as predictor of dyslipidemia (P < 0.01). Duration T2DM is associated with increased risk of having higher TC (P < 0.05), LDL (P < 0.05) and lower HDL (P < 0.01) and does not seem to affect triglyceride (P > 0.05). T2DM with comorbid hypertension seems to predict hyper tri-glyceridemia and lower HDL. Both TC–HDL ratio and LDL–HDL ratio appeared as good predictor of all four parameters of dyslipidemia (P < 0.01). The characteristic features of diabetic dyslipidemia are low HDL, high triglyceride and LDL cholesterol level. Low HDL level is the most frequent type of abnormality.
CONCLUSIONS: Poor glycemic control, prolonged duration, coexisting hypertension predicts dyslipidemia in T2DM.