Association of dietary MUFA intake with HDL profile measurements in Japanese men and women living in Japan and Hawaii: INTERLIPID Study

Sunday, 17 August 2014: 4:45 PM
Tubughnenq 4 (Dena'ina Center)
Maryam Zaid, MS , Shiga University of Medical Science, Otsu, Japan
Katsuyuki Miura, MD , Shiga University of Medical Science, Otsu, Japan
Yoshitaka Murakami, PhD , Shiga University of Medical Science, Otsu, Japan
Nagako Okuda, MD , National Institute of Health and Nutrition, Tokyo, Japan
Akira Okayama, MD , Japan Anti-Tuberculosis Association, Tokyo, Japan
Kiyomi Sakata, MD , Iwate Medical University, Iwate, Japan
Kamal B Masaki, MD , University of Hawaii, Honululu, HI
Beatriz Rodriguez, MD , University of Hawaii, Honolulu, HI
Jeremiah Stamler, MD , Northwestern University, Chicago, IL
Hirotsugu Ueshima, MD , Shiga University of Medical Science, Otsu, Japan
INTRODUCTION:  

Effects of dietary monounsaturated fatty acid (MUFA) on high-density lipoprotein (HDL) profile are limited. We analyzed the associations between total MUFA and oleic acid intake with cholesterol content, particle concentration, and size categories of HDL.

METHODS:  

Participants of the cross-sectional INTERLIPID Study (958 participants: 463 male and 495 female), aged 40-59 years, who were randomly selected from populations in Japan and Hawaii were assessed. MUFA intake was estimated from the mean of four in-depth 24-hour dietary recalls (% kcal per day). Exclusion criteria included use of lipid lowering medication and missing data on HDL profile. Serum total HDL particle (HDL-P), HDL size subclass, and mean HDL size were measured using nuclear magnetic resonance. HDL cholesterol (HDL-C) was measured using standard lipid methods. Multiple linear regression models were sex-stratified and adjusted for base covariates: age, country, body mass index, diabetes, hypertension, smoking status, alcohol intake and physical activity index.

RESULTS:  

In men, MUFA intake was positively and significantly associated with HDL-P:  1 standard deviation (SD) increase in MUFA was associated with 0.21 [95% confidence interval: 0.11 to 0.30]SD of HDL-P, p<0.01. This association maintained significance, although was slightly attenuated after further adjustments for HDL-C (0.15 [0.06 to 0.23]SD, p<0.01) and additionally for polyunsaturated fatty acid (PUFA) intake (0.13 [0.02 to 0.23]SD, p=0.02). HDL-C and small and large HDL were significantly associated with MUFA, but did not maintain their associations in models adjusted for HDL-P and PUFA.

In women, only HDL-P was positively associated with MUFA (0.1 [0.01 to 0.19]SD p=0.04) with adjustment for HDL-C and PUFA.

Oleic acid had similar results. 

CONCLUSIONS:  

Total MUFA and oleic acid intake were significantly associated with total particle and cholesterol concentration of HDL. Associations of MUFA with HDL-P were independent of HDL-C, whereas other HDL profile measurements were generally not independent of HDL-P.

See more of: Nutrition and Diet, 1: Free Papers
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